Investigation of the effects of Zinc oxide nanoparticles synthesized by Saccharomyces cerevisiae aqueous lysate on in-vitro wound healing model

Objective: The objective of this study was to examine the toxic and wound-healing behaviours zinc oxide (ZnO) nanoparticles synthesized with an aqueous lysate sourdough (Saccharomyces cerevisiae) on L929 mouse fibroblast cells.Method: Zinc were by microwave method using Saccharomyces cerevisiae. Characterization ZnO accomplished Ultraviolet-Visible region spectroscopy (UV-Vis), SEM Zeta sizer. behavior ZnONPs at concentrations 1, 10, 100, 1000 µg/mL their effects wound healing investigated in-vitro in cells.Results: A sharp peak observed 360-380 nm specific UV spectrum. In zeta analysis, mean size 512.8±16 charge -30.38±3.12 mV. It found that cells treated did not show dose-dependent manner. significant increase closure amount applied 100 compared control group cells.Conclusion: In-vitro cerevisiae these have potential be used pharmaceutical cosmetic industries.